Can you activate a RemoteEvent without a script in StarterPlayerScripts?

Currently, I have my ServerScript for firing the event and RemoteEvent in the ServerScriptService and I have the LocalScript in a PlayerGui. Is it possible to fire this RemoteEvent or is it not possible?

No, clients cannot access the serverscriptservice.

This question is confusing. Do you have the remote in ServerScriptService? It should be in a place accessible to both the server and client, like ReplicatedStorage. The LocalScript does not need to be in PlayerScripts but in a place where they can run

I explained incorrectly. The RemoteEvent and the ServerScript are in the ReplicatedStorage. Sorry. Does this help?

Scripts do not run in ReplicatedStorage. They only run in Workspace, ServerScriptService and Backpack.