Using multiple DataStore2's?

Is using multiple datastore2’s as bad of an idea as using multiple normal datastores?

I took a look at dev console in my game today, and got flooded with throttled datastore requests, mainly because I autosave 3 datastores at once every 1 minute.

So can I safely use multiple DataStore2’s?
Or should I combine everything into 1 giant table?

You can use Datastore2.Combine to have them automatically be stored in one giant table. Storing things in one table is better on the datastore budget, and you rarely need the full 260k chars.