This bug happens to me sometimes, but not odten. Select a part in the explorer tab, press F to go to it, and then you should have the ability to rotate your camera, select parts, if not then you have a unique problem.
It is something to do with collision groups. For me it was that default was set to not collide with itself that broke it.
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I found a better solution you just have to find that invisible frame (for me it was a invisible frame) and then just toggle the “Interactable” property.
It will tell studio that you’re not interacting with the invisible frame but with the game itself.
Edit: Apparently it disables everything inside of it too… Maybe it wasn’t a better solution. 
yea, ever since roblox created that property, UIs have been 10x more annoying to manage.
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I highly agree with you, House_Owner. 
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I found a ACTUAL fix and it is to just toggle the “Active” property on the element that is blocking your mouse.
This HAS to work.
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