Creating gui in StarterGui or by a script?

Are there any performance differences between creating a gui with a script and just making it in StarterGui? I find creating guis with scripts to be easier to manage but I am concerned if it will impact performance of the game

I can’t imagine there is much of a performance difference in scripting it versus StarterGui. I hate making Guis, so laying them out in StarterGui is easier and a less painful method I find.