How would you enable only one slot in Players Inventory

I am wondering, how would you disable all the slots of a players inventory except for one? (I am making a game where you can get multiple weapons aka skins and need to make it so that the player can only have access to the skin they select using a gui)

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I would suggest just making a custom toolbar

Iā€™m pretty sure that if I just make a custom tool bar, the slots are still enabled? (Even if it is not shown)