This issue is still occurring, 5 years later. When I try to press the Escape key to activate an InputBegan event, nothing happens. I believe the issue also persists with the Tab key.
Also, as @AxeOfMen mentioned in Aug 2016, sometimes when using the Alt+P shortcut, it will instead insert “p” into the script body instead of publishing the game.
Any updates in the past few years, @Silent137?
UPDATE 1 (of probably many, 12/17/21): I’ve discovered that if you’re focused in a TextBox, it seems like the Escape key works. The Tab key works fine in Studio now, but the Escape key only works if you’re focused in a TextBox, and then press Escape.